A new sensor is giving researchers the best look yet at ATP levels inside living cells, enabling scientists to study in greater detail than ever before how fluctuations in this cellular currency affect the cell and contribute to disease.
To date, approaches to treatments for Alzheimer's disease have not addressed the contribution of protein insolubility as a general phenomenon, instead focusing on one or two insoluble proteins. Researchers have recently completed a systematic study in worms that paints an intricate picture of the connections between insoluble proteins in neurodegenerative diseases and aging. Furthermore, the work demonstrated an intervention that could reverse the toxic effects of the aggregates by boosting mitochondrial health.
Being stressed while witnessing injustice may push your brain towards altruism, according to a new study.
Sea otters are one of the few animals that use tools to access their food, and a new study has found that individual sea otters that use tools -- most of whom are female -- are able to eat larger prey and reduce tooth damage when their preferred prey becomes depleted.
Chemotherapy kills cancer cells. But the way these cells die appears to be different than previously understood. Researchers have now uncovered a completely new way in which cancer cells die: due to the Schlafen11 gene. 'This is a very unexpected finding. Cancer patients have been treated with chemotherapy for almost a century, but this route to cell death has never been observed before. Where and when this occurs in patients will need to be further investigated. This discovery could ultimately have implications for the treatment of cancer patients.'
Researchers have determined that a protein prediction technology can yield accurate results in the hunt to efficiently find the best possible drug candidates for many conditions.
A team of chemists has achieved a significant breakthrough in the field of chemical synthesis, developing a novel method for manipulating carbon-hydrogen bonds. This groundbreaking discovery provides new insights into the molecular interactions of positively charged carbon atoms. By selectively targeting a specific C--H bond, they open doors to synthetic pathways that were previously closed -- with potential applications in medicine.
In an important step toward more effective gene therapies for brain diseases, researchers have engineered a gene-delivery vehicle that uses a human protein to efficiently cross the blood-brain barrier and deliver a disease-relevant gene to the brain in mice expressing the human protein. Because the vehicle binds to a well-studied protein in the blood-brain barrier, the scientists say it has a good chance at working in patients.
Researchers have developed a method to investigate sperm whale communication by determining their vocal style, finding that groups living in close proximity can develop similar styles to each other.
In a groundbreaking study an international team of scientists has investigated the evolutionary patterns behind the development of sabre teeth, with some unexpected results along the way.
Researchers have investigated how spiders listen to their environments through webs and found that the webs match the acoustic particle velocity for a wide range of sound frequencies. Playing sound ranging from 1 Hz to 50 kHz for the spiders and measuring the spider silk motion with a laser vibrometer, they found the sound-induced velocity of the silk was the same as the particles in the air surrounding it. This confirmed the mechanism that these spiders use to detect their prey.
Sarcasm is notoriously tricky to convey through text, and the subtle changes in tone that convey sarcasm often confuse computer algorithms as well, limiting virtual assistants and content analysis tools. So researchers have now developed a multimodal algorithm for improved sarcasm detection that examines multiple aspects of audio recordings for increased accuracy. They used two complementary approaches -- sentiment analysis using text and emotion recognition using audio -- for a more complete picture.
Many people are concerned about residues of chemicals, contaminants or microplastics in their food. However, it is less well known that many foods also contain toxins of completely natural origin. These are often chemical compounds that plants use to ward off predators such as insects or microorganisms. These substances are found in beans and potatoes, for example, and can pose potential health risks.
What features does a robotic guide dog need? Ask the blind, say researchers. A new study identifies how to develop robot guide dogs with insights from guide dog users and trainers.
Singing rehabilitates speech production in post-stroke aphasia. Researchers investigated the rehabilitative effect of singing on the brain.
Researchers have found that persimmon tannin, known for its antioxidant properties, improves the growth of yeast in the presence of ethanol.
The treatment of animals rates higher than green issues when consumers choose meat and dairy products. That's according to a new study, which suggests that while consumers consider sustainability important, other factors such as taste, quality, and animal welfare take precedence in their purchasing decisions.
Perceiving something -- anything -- in your surroundings is to become aware of what your senses are detecting. Today, neuroscientists identify, for the first time, brain-cell circuitry in fruit flies that converts raw sensory signals into color perceptions that can guide behavior.
After spinning for under two years, a wind farm can offset the carbon emissions generated across its entire 30-year lifespan, when compared to thermal power plants.
Celiac disease is a chronic autoimmune condition that occurs in around one per cent of the world's population. It is triggered by the consumption of gluten proteins from wheat, barley, rye and some oats. A gluten-free diet protects celiac patients from severe intestinal damage.
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